TITLE:
Evaluation of Serum Trace Elements and Vitamin Levels in Hashimoto’s Thyroiditis: Single Centre Experience from Turkey
AUTHORS:
Fatma Dilek Dellal, Mutlu Niyazoglu, Esranur Ademoglu, Suheyla Gorar, Zehra Candan, Handan Bekdemir, Ziynet Alphan Uc, Mehmet Senes, Aysenur Ozderya, Yalcin Aral
KEYWORDS:
Hashimoto’s Thyroiditis; Trace Element; Vitamin, Vitamin B12, Atrophic Gastritis; Anti Thyroid Peroxidase Antibody
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.3 No.4,
July
23,
2013
ABSTRACT: Aim: To determine levels of serum trace elements
and vitamins, and to find out possible correlations between these elements and
vitamins with thyroid function tests and thyroid autoantibody levels in
patients having Hashimoto’s thyroiditis (HT). Methods: The study
included 51 premenauposal women with untreated HT, aged 18 to 56 years without
any known chronic diseases or chronic medicine usage, and 27 healthy
premenauposal women aged 19 to 42 years old. Trace elements (selenium, zinc,
copper, iron levels) and vitamins [A, E, B12, 25-OH-D, 1,25(OH)2D
and folic acid levels] were evaluated in patient and control groups. Results: Consequently, serum trace elements and vitamin B12 levels did not significantly
differ in patients with HT and control group. Thyroid functioning tests and
autoantibody levels did not show any correlation with the levels of trace
elements, vitamin A, vitamin E and 25-OH vitamin D. A correlation was detected
between vitamin B12 and Anti thyroid peroxidase levels. Conclusion: The
negative correlation between vitamin B12 and Anti thyroid peroxidase levels may
demonstrate the necessity to screen the patients with HT for atrophic
gastritis. We believe that more comprehensive studies with larger sample sizes
are needed in which patients are randomized according to their nutritional
status.