Moreno, D., Zalba, S., Colom, H., Trocóniz, I.F., Tros de Ilarduya, C. and Garrido, M.J. (2009) Biopharmaceutic and pharmacodynamic modeling of the in vitro antiproliferative effect of new controlled delivery systems of cisplatin. European Journal of Pharmaceutical Sciences, 37, 341-350. doi:10.1016/j.ejps.2009.03.005

has been cited by the following article:

• TITLE: Controlled release of cisplatin and cancer cell apoptosis with cisplatin encapsulated poly(lactic-co-glycolic acid) nanoparticles

  AUTHORS: A. Champa Jayasuriya, Anthony J. Darr

  KEYWORDS: Nanoparticles, Cisplatin; Poly(Lactic-co-Glycolic Acid); Controlled Release; Cancer; Apopotosis

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.6 No.5, May 27, 2013

  ABSTRACT: The goal of the present study is to utilize cis-diamminedichloroplatinum (cisplatin) loaded polymer nanoparticles (NPs) to give a controlled, extended, and local drug therapy for the treatment of cancer. We have used biodegradable and biocompatible poly(lactic-co-glycolic acid) (PLGA) to prepare the NPs by adjusting the double emulsion technique using poly(vinylalcohol) as a surface active agent. The PLGA NPs were characterized for particle size and shape, controlled release of cisplatin, and degradation. Cisplatin solubility in deionized water was increased up to 4 mg/mL by simply changing the solution parameters. Cisplatin encapsulated NPs were incubated in phosphate buffered saline (PBS) at 37?C to study the release kinetics of cisplatin. Cisplatin was released in a sustained manner with less than 20% release during a 3-day period followed by 50% release during a 21-day period. A degradation study of PLGA NPs demonstrated the loss of spherical shape during a 21-day period. We also examined the cisplatin sensitive A2780 cell apoptosis when cells were incubated with cisplatin encapsulated PLGA NPs. A large number of cell apoptosis occurred as a result of cisplatin release from the PLGA NPs. These results suggest that cisplatin encapsulated PLGA NPs can be used to treat the cancer cells by injecting them into a localized site minimizing the side effects.