Y. Nishikawa, T. Shindo, K. Ishii, H. Nakamura, T. Kon and H. Uno, “cryamide Derivatives as Antiallergic Agents. I. Synthesis and Structure-Activity Relationships of N[(4-Substituted 1-Piperazinyl)Alkyl]-3-(Aryl and Heteroaryl) Acryamides,” Chemical & Pharmaceutical Bulletin, Vol. 37, No. 1, 1989, pp. 100-105. doi:10.1248/cpb.37.100

has been cited by the following article:

• TITLE: Synthesis of Some N-[(4-Substituted-1-Piperazinyl)-Oxo(Alkyl and Ethylcarbamoyl)]-3-(2-Thiophenyl)Acrylamides as Non-Steroidal Anti-Allergic and Anti-Inflammatory Agents

  AUTHORS: Osama I. Abd El-Salam, Ahmed M. Shalaby, Abdulah A. El-Sawy, Soha Elshihaby, Mohamed Abdulla

  KEYWORDS: Thiophene; Amino Acids; Piperazines; Anti-Allergy; Ant-Inflammatory

  JOURNAL NAME: Open Journal of Synthesis Theory and Applications, Vol.2 No.2, April 9, 2013

  ABSTRACT: An interesting approach for the design of anti-allergies is rationally considered. It was proved that current anti-allergic drugs comprise piperazine and acrylic acid segments. In harmony with these findings, new products 5a-u were synthesized starting from conjugated 2-thiopheneacrylic acid with amino acid esters3a-g followed by coupling of their acid derivatives4a-g with some piperazine segments, with the aim to increase their biological activities and decrease side effects. The anti-allergic and anti-inflammatory activities of the products were evaluated and promising results were obtained.