Richter, A.M., Jain, A.K., Canaan, A.J., et al. (1992) Photosensitizing efficiency of two regioisomers of the ben zoporphyrin derivative monoacid ring A (BPD-MA). Bio chemical Pharmacology, 43, 2349-2358. doi:10.1016/0006-2952(92)90313-8

has been cited by the following article:

• TITLE: Monitoring vascular changes induced by photodynamic therapy using contrast-enhanced micro-computed tomography

  AUTHORS: Otilia C. Nasui, Stuart K. Bisland, Nancy L. Ford

  KEYWORDS: Micro-Computed Tomography; Contrast Agent; Animal Model; Photodynamic Therapy; Cancer

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.6 No.2, February 27, 2013

  ABSTRACT: The aim of this study was to determine whether contrast-enhanced micro-computed tomography can be used for non-invasive imaging of the early-stage changes in the vasculature of tumours that have been treated with photodynamic therapy (PDT). The subjects used were C3H mice with an RIF-1 tumour implanted subcutaneously and allowed to grow for 3 weeks prior to treatment. The experimental groups were PDT-treated (150 J/cm2 and 50 J/cm2) and control (150 J/cm2 light-only and untreated). The laser light exposure was performed at 15 - 30 minutes after the administration of the photosensitizer (BPD-MA). The contrast-enhanced micro-computed tomography imaging procedure consisted of eight-second scans taking place before treatment and up to 24 hours after treatment. The 150 J/cm2 PDT group showed a significant increase in the ratio of blood volume to tumour volume at 2, 8 and 24 hours after treatment when compared to pre-treatment measurements (p 2 PDT group at 24 hours after treatment. This preliminary study indicates that micro-CT can detect compromised vasculature in tumours treated with high-fluence photodynamic therapy as early as 2 hours post treatment.