TITLE:
Clinical Impact of Endoscopic Submucosal Dissection for Early Gastric Cancer
AUTHORS:
Takashi Kosaka, Masaki Endo, Yousuke Toya, Tomomi Mizutani, Yukito Abiko, Norihiko Kudara, Masaaki Inomata, Toshimi Chiba, Yasuhiro Takikawa, Kazuyuki Suzuki, Tamotsu Sugai
KEYWORDS:
Endoscopic Submucosal Dissection; ESD; Gastric Cancer
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.4 No.1A,
January
21,
2013
ABSTRACT:
Aim: The aim of this study was to examine the safety and efficacy of endoscopic submucosal dissection (ESD) for early gastric cancer based on approximately 10 years’ experience. Methods: Endoscopic submucosal dissection was performed in 1272 patients with early gastric cancer (1657 lesions). We examined en bloc resection rate, curative resection rate, local recurrence rate, procedure time, and complications. Results: The overall en bloc resection rate was 98.6% for all lesions treated by ESD. The median procedure time of the operation was 54.3 minutes (range 5 - 632 min). The incidence of positive horizontal and vertical margins was 3.8% and 4.0%, respectively. The incidence was 2.5% each for perforation and postoperative bleeding. There were no deaths related to ESD. Local recurrence was observed in 10 lesions (0.06%). Conclusion: Since the procedure time and incidence of complications have been reduced, endoscopic submucosal dissection has been considered a standard treatment for early gastric cancer.