N. M. O’Boyle, M. Carr, L. M. Greene, N. O. Keely, A. J. S. Knox, T. McCabe, D. G. Lloyd, D. M. Zisterer and M. J. Meegan, “Synthesis, Biochemical and Molecular Modelling Studies of Antiproliferative Azetidinones Causing Microtubule Disruption and Mitotic Catastrophe,” European Journal of Medicinal Chemistry, Vol. 46, No. 9, 2011, pp. 4595-4607. doi:10.1016/j.ejmech.2011.07.039

has been cited by the following article:

• TITLE: Microwave Assisted and Al2O3/K2CO3 Catalyzed Synthesis of Azetidin-2-One Derivatives Containing Aryl Sulfonate Moiety with Anti-Inflammatory and Anti-Microbial Activity

  AUTHORS: Babasaheb V. Kendre, Mahadev G. Landge, Sudhakar R. Bhusare

  KEYWORDS: Aldimine; Azetidin-2-One; Anti-Inflammatory; p-Amino Benzoic Acid; 2-Amino Pyridine; p-Toluene Sulfonyl Chloride

  JOURNAL NAME: Open Journal of Medicinal Chemistry, Vol.2 No.3, September 27, 2012

  ABSTRACT: We report the novel synthesis of azetidin-2-one derivatives containing aryl sulfonate moiety from the reaction of 2-hydroxy benzaldehyde with p-toluene sulfonyl chloride afforded firstly 2-formylphenyl 4-methylbenzene sulfonate (2). The compound (2) on reaction with p-aminobenzoic acid or 2-aminopyridine gave the corresponding aldimines (3). Furthermore, the aldimines are on reaction with chloroacetyl chloride gives corresponding azetidin-2-ones in good to moderate yield. Among the eight synthesized azetidin-2-ones, five selected compounds have been screened for the an-ti-inflammatory activity, few of them showed good anti-inflammatory activity compared with standard drugs. Anti- microbial activity of all synthesized compounds has been tested and most of the compounds showed good anti-bacterial and anti-fungal activities.