TITLE:
Comparison between Different Modalities of Treatment of Ewing Sarcoma
AUTHORS:
Ranadeb Bandyopadhyay, Arindam Mukherjee, Ujjal Bhakat
KEYWORDS:
Ewing Sarcoma; EBRT; Chemotherapy; Surgery; Kaplan-Meier Survival Curves; Cox Proportional Hazards Model
JOURNAL NAME:
Open Journal of Orthopedics,
Vol.2 No.2,
June
22,
2012
ABSTRACT: Background: Ewing sarcoma is the most common primary malignant tumour in patients younger than 10 years of age. The incidence is less than 1 per 1 million per year. Usually it is located in the diaphysis of long bones. Prognosis of these tumours has improved dramatically since the introduction of multi-agent chemotherapy, from an erstwhile 10% survival rate to the current 70% for patients with non-metastatic Ewing sarcoma. Method: A retrospective review of patients with histologically confirmed Ewing sarcoma who were treated in the Department of Orthopaedics, B.S. Medical College during the time period from April 2000 to March 2012 was performed. Patients were divided into two groups: Group A included those treated by External Beam Radiotherapy (EBRT) + chemotherapy while Group B included the patients treated with surgery + chemotherapy. Results were analysed depending on the survival rates. Kaplan-Meier survival curves were compared using log-rank test and a multivariate Cox proportional hazards model was calculated. Result: The survival curves of both the groups were not found to be significantly different. Conclusion: Treatment of Ewing tumour has multiple options. No one treatment modality is superior. Survival rates of patients treated by radiation + chemotherapy are not significantly different from those treated with surgery + chemotherapy.