TITLE:
Prevalence and Psychosocial Factors of Serodiscordance in Couples Followed at the Centre of Excellence in Lubumbashi, Democratic Republic of the Congo
AUTHORS:
Manda Mukendi Dodo, Lokotshe Kanyama Astrid, Tshibangu Manyonga Emmanuel, Mbuyamba Mutombo Nathalie, Kalumba Kambote Athy, Nyembo Lukamba Jerome, Kandja Lwamba Guy, Elo Mbomba David, Njibu Ebondo Jirene, Panshi wa Panshi Odon, Mbayo Malemba Jerry, Kasamba Ilunga Eric, Mulwani Makelele Basile, Lungu Anzwal Philomene
KEYWORDS:
HIV, Serodiscordance, PrEP, Stigma, Social Support, Lubumbashi, Couple
JOURNAL NAME:
World Journal of AIDS,
Vol.16 No.3,
August
31,
2026
ABSTRACT: Introduction: Serodiscordance where one partner in a couple is HIV-positive and the other is HIV-negative—poses a major challenge in the fight against HIV/AIDS, particularly in sub-Saharan Africa. Despite its epidemiological relevance, little is known about this phenomenon in Lubumbashi, Democratic Republic of the Congo (DRC). Methods: A cross-sectional study was conducted from January 15 to March 31, 2025 at the Lubumbashi Center of Excellence for HIV/AIDS. A total of 132 couples were enrolled. Data were collected using structured questionnaires, validated scales (HSS-10 for stigma, MOS for social support), and medical records. Statistical analysis was performed using Jamovi software (version 2.4). Results: Serodiscordance prevalence was 68.2%. Pre-exposure prophylaxis (PrEP) was used by only 8.3% of participants, and consistent condom use was reported by 14.4%. High perceived stigma was associated with a 40% decrease in antiretroviral adherence (OR = 0.60; p Conclusion: Serodiscordant couples are highly prevalent in Lubumbashi but remain underserved. Social stigma, lack of education, and structural barriers limit the effectiveness of biomedical prevention strategies. Community-based interventions and improved access to HIV prevention tools are urgently needed.