TITLE:
Deficiency of Factor V of Coagulation: About a Case
AUTHORS:
Amadou Djibrilla-Almoustapha, Badé Malam-Abdou, Maman-Brah Mousatapha, Moustapha Elhadji-Chefou, Oumarou Adamou-Chaibou, Moubarak Bouwe-Abdou, Oumoulkairou Abdoulaye-Soumana, Haoua Amadou-Adamou, Aziz Bassirou-Garba, Abdoulaye Hama-Moussa, Oubeida Ibrahim-Oumara, Mariama Maikabi-Nomaou, Balkissa Mamoudou-Idrissa, Ibrahim Samna-Kona
KEYWORDS:
Factor V Deficiency, Onco-Hématology, National Hospital of Niamey
JOURNAL NAME:
Open Journal of Blood Diseases,
Vol.16 No.1,
March
19,
2026
ABSTRACT: Context: Factor V deficiency is a rare abnormality of coagulation as para-haemopilia, originally described by Owren in 1947, it is transmitted in an autosomal and recessive fashion. Its incidence is estimated at 1/10,000 in France. Clinical expressive is usually asymptomatic in the homozygous state. The diagnosis is based on a low prothrombin rate and normal TCK associated with a decrease in the factor of PFC in our context. Results: This was a 16-year-old male patient of normal build, born to consanguineous parents. He had sustained a head injury with the formation of an occipito-parietal hematoma. On admission, he was conscious, with moderate pallor of the skin and mucous membranes. The Complete Blood Count (CBC) showed normocytic anemia, a normal white blood cell and platelet count, PT at 59.5% and Activated Partial Thromboplastin Time (aPTT) Normal. Factor assays using a chronometric method revealed a factor V deficiency with normal factor VII. The patient received six transfusions of Fresh Frozen Plasma (FFP). The outcome was favorable, with progressive resorption and disappearance of the hematoma within a few days. Conclusion: Factor V deficiency is a very rare blood clotting disorder. It affects men and women equally and can, in some cases, cause significant bleeding.