TITLE:
Antidiabetic and Antioxidant Potentials of Aqueous Fresh Leaf Extract of Chrysophyllum albidum in Streptozotocin-Induced Diabetic Rats
AUTHORS:
Victor Ugadu Nwankwo, Kingsley Nwonu Agbafor, Nkiru Nwamaka Ezeanni, David Chukwu Obasi, Emmanuel Nnaemeka Uhuo, Shedrack Ifeanyi Nwodo
KEYWORDS:
Chrysophyllum albidum, Diabetes, Antioxidants, Phytochemicals and Albino Rats
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.13 No.11,
November
11,
2025
ABSTRACT: Traditional medicine practitioners in Eastern Nigeria use various parts of Chrysophyllum albidum in management and treatment of several disorders, including liver and pancreatic ones. This study investigated antidiabetic and antioxidant potentials of aqueous fresh leaf extract of Chrysophyllum albidum in streptozotocin (STZ)-induced diabetic rats. Phytochemicals content and acute toxicity of the extract were measured by standard procedures. Forty-two (42) adult male albino rats, placed in seven groups (A, B, C, D, E, F and G) of six rats each, were used. Diabetes was induced in groups B - G by intraperitoneal administration of 50 mg/kg body weight of STZ. Groups D, E, F and G were treated with 200, 400, 600 and 800 mg/kg body weight of the extract respectively, while group C was given 500 mg/kg body weight of metformin. Treatment was by oral intubation, and lasted for twenty-one consecutive days. The results revealed percentage of cardiac glycosides > flavonoids > saponins > terpenoids > alkaloids > phenols > tannins in the extract. The median lethal dose (LD50) of the extract was estimated to be greater than 5000 mg/kg b.wt. Induction of diabetes resulted to a significant (P Chrysophyllum albidum including management/treatment of diabetes.