TITLE:
Assessment of Histopathological and Blood Biochemical Profiles in Dairy Cattle Treated with an Experimental Intramuscular Fasciolicide
AUTHORS:
Froylán Ibarra-Velarde, Rosa Arias-García, Yolanda Vera-Montenegro, Miguel Flores-Ramos, Gerardo Leyva-Gómez, Alicia Hernández-Campos
KEYWORDS:
Fasciola Hepatica, Triclabendazole, Fosfatriclaben, Adverse Drug Reaction
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.16 No.10,
October
14,
2025
ABSTRACT: The aim of this work was to determine whether intramuscular administration of injectable fasciolicide fosfatriclaben, in a single dose at 6 mg/kg in dairy cattle, produces adverse reactions manifested through blood biochemical and histopathological profiles, especially in organs involved in drug metabolism. For the study, nine out of ten Holstein-Freisian dairy cows were treated, leaving one cow untreated as a control. On days 0, 7, 14, and 28 post-treatment, liver, kidney, and injection site samples were taken for histopathology, as well as blood samples for biochemical analysis. The results showed no histopathological changes, and the analyte values in biochemical tests remained within the reference range, suggesting the compound has a favorable safety profile.