TITLE:
A Promising TNF-α Inhibition Activity of 2-Aminocyclopentenylphosphonates
AUTHORS:
Abed Al Aziz Al Quntar, Ahmad Quntar, Mira Shatat, Ibrahim Abasy, Imad Matouk
KEYWORDS:
Phosphonates, Aminophosphonates, Cyclopentenylphosphonate, TNF-α, Inflammation, Budesonide, Rheumatoid Arthritis
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.13 No.8,
August
13,
2025
ABSTRACT: Buoyed by our previous TNF-α results, three 2-amino-1-cyclopentenylphos-phonate compounds which were synthesized by the reaction of diethyl 5-chloro-1-pentynylphosphonate with various amines exhibited promising TNF-α inhibitory activity.