TITLE:
Advancing Atherosclerosis Management: Innovative Targeted Cell Therapy Approaches to Reverse Disease Progression and Enhance Vascular Health
AUTHORS:
Shanmukh Reddy, Terry Oroszi
KEYWORDS:
Atherosclerosis, Targeted Cell Therapy, Stem Cells, Regenerative Medicine, Endothelial Progenitor Cells (EPCs), Monocyte/Macrophage Modulation, Vascular Repair, Immune Modulation, Gene Therapy
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.15 No.7,
July
31,
2025
ABSTRACT: Atherosclerosis, which is defined by plaque accumulation within artery walls, is one of the leading causes of cardiovascular disease and mortality. Although they help control symptoms and slow the condition’s progression, traditional treatments, including medication, surgery, and lifestyle changes, do not address the underlying pathophysiology. Recent innovations in targeted cell therapy, such as gene editing, stem cell therapy, and exosome-based therapies, present encouraging methods for repairing endothelium damage, lowering inflammation, and restoring vascular health. This study examines how different therapy approaches are related, highlighting the potential of regenerative medicine to stop the progression of atherosclerosis. Despite the potential of these developments, issues such as financial constraints, regulatory obstacles, patient-specific efficacy variability, and safety concerns must be resolved. More research and technical developments are essential to incorporate these treatments into clinical practice, improve patient outcomes, and reduce the prevalence of cardiovascular disease worldwide.