Humphries, C., Addison, M., Aithal, G., Boyd, J., Briody, L., Campbell, J.D.M., et al. (2024) Macrophage Therapy for Acute Liver Injury (MAIL): A Study Protocol for a Phase 1 Randomised, Open-Label, Dose-Escalation Study to Evaluate Safety, Tolerability and Activity of Allogeneic Alternatively Activated Macrophages in Patients with Paracetamol-Induced Acute Liver Injury in the UK. BMJ Open, 14, e089417.
https://doi.org/10.1136/bmjopen-2024-089417

has been cited by the following article:

• TITLE: Occult Life-Threatening Acetaminophen Toxicity in an Elderly Patient Presenting with Confusion: A Case Report

  AUTHORS: Laura Devleesschauwer, Marc Sabbe, Thiru Govindan

  KEYWORDS: Acetaminophen Toxicity, Screening, Altered Consciousness, Emergency Medicine

  JOURNAL NAME: Case Reports in Clinical Medicine, Vol.14 No.7, July 18, 2025

  ABSTRACT: Acetaminophen overdose is a common and potentially life-threatening cause of acute liver injury. While intentional overdoses are widely acknowledged, occult overdoses often remain overlooked, especially in vulnerable populations such as older adults. This can be associated with a significant risk of clinical deterioration due to delayed diagnosis and timely delivery of antidote treatment. We present the case of a 68-year-old man who unknowingly consumed supratherapeutic doses of acetaminophen, unaware of the drug’s potential for harm. This led to a high anion gap metabolic acidosis, multiple organ failure, including encephalopathy and severe hepatotoxicity. This case emphasizes the critical need to consider acetaminophen toxicity in patients with altered mental status and highlights the importance of early recognition, timely initiation of N-acetylcysteine therapy, and increased vigilance in elderly patients and patients who present with altered mental status or unexplained high anion gap metabolic acidosis.