TITLE:
Comparative Efficacy and Safety of a Horse Chestnut Formulation vs. Diosmin-Hesperidin in Chronic Venous Insufficiency: Randomized Double-Blind Trial
AUTHORS:
Carlos Romualdo B. Gama, Carlos P. Nunes, Marcio Steinbruch, Mendel Suchmacher, Gustavo Falcão Gama, Renato Kaufman, Spyros Mezitis, Aline Levy Sitnoveter, Thais Gotfyd Bem Ezri, João Paulo L. Daher, Mauro Geller
KEYWORDS:
Chronic Venous Insufficiency, Aesculus hippocastanum and Associations, Diosmin-Hesperidin
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.16 No.6,
June
25,
2025
ABSTRACT: Background: Chronic venous insufficiency (CVI) is a prevalent and incurable condition that can be managed through both medical and surgical interventions. Objective: To compare the safety and efficacy of a combination of Aesculus hippocastanum, Polygonum acre, Smilax papyracea, and rutin (Group A; nA = 60) versus a combination of diosmin-hesperidin (Group B; nB = 60), over a 90-day treatment period, in patients with symptoms consistent with CVI. Methods: Efficacy and safety were assessed using both self-paired and comparative study designs. Study endpoints included: 1) Severity of venous symptoms measured by the Visual Analogue Scale (VAS), 2) Quality of life via the CIVIQ-20 score, 3) Physician’s assessment score, 4) Patient’s self-assessment score, and 5) Ease of swallowing the pharmaceutical form, assessed by VAS. Safety profiles were also evaluated. Results: The Group A combination was statistically non-inferior to the Group B combination across all study endpoints, including venous symptom severity, quality of life, and both physician and patient assessments. Group A’s formulation was reported to perform better on quality-of-life (CIVIQ-20 score-Visit 3) (p Conclusion: Both regimens were safe and effective, with Group A showing better general performance in relation to Group B.