Radovanovic, M., Day, R.O., Jones, G.D.R., Galettis, P. and Norris, R.L.G. (2022) LC–MS/MS Method for Simultaneous Quantification of Ten Antibiotics in Human Plasma for Routine Therapeutic Drug Monitoring. Journal of Mass Spectrometry and Advances in the Clinical Lab, 26, 48-59.
https://doi.org/10.1016/j.jmsacl.2022.11.001

has been cited by the following article:

• TITLE: Determination of Nifuratel in Human Plasma by Using Liquid Chromatography-Tandem Mass Spectrometry and Its Application to a Pharmacokinetic Study

  AUTHORS: Nihal Saraner, Gökçe Demiray, Berrak Güney, Onursal Sağlam

  KEYWORDS: Nifuratel, Nifuratel 13C D3, Human Plasma, LC-MS/MS, Bioequivalence

  JOURNAL NAME: Open Journal of Applied Sciences, Vol.15 No.5, May 28, 2025

  ABSTRACT: In this study, a rapid, straightforward, and sensitive method was developed and validated for the quantification of nifuratel (NIF) in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Plasma samples were processed using liquid-liquid extraction with nifuratel 13C D3 as the internal standard (IS). Chromatographic separation was achieved on a Waters ACQUITY UPLC BEH C18 (1.7 µm, 2.1 × 50 mm) column using a mobile phase consisting of formic acid, water, and acetonitrile at a flow rate of 0.60 mL/min. NIF was identified and quantified via mass spectrometry with electrospray ionization (ESI) in positive ion mode and multiple reaction monitoring (MRM). The method showed linearity in the range of 0.25 - 150 ng/mL for NIF. The developed and validated method was applied to the bioequivalence study in human plasma samples.