TITLE:
Neurosurgical Aspects of Growth Hormone Pituitary Adenomas at Fann Teaching Hospital
AUTHORS:
Maguette Mbaye, Emmanuel Dadet, Hugues Ghislain Atakla, Daouda Wague, Mbaye Thioub, Nantenin Doumbia, Alioune Badara Thiam, Momar Code Ba
KEYWORDS:
Acromegaly, Pituitary Adenoma, GH, Senegal
JOURNAL NAME:
Open Journal of Modern Neurosurgery,
Vol.15 No.2,
February
6,
2025
ABSTRACT: Introduction: Somatotropic adenomas are benign pituitary tumors characterized by increased GH and IGF1 levels. This study aims to describe the demographic, therapeutic, clinical, and evolutionary aspects of patients with somatotropic adenoma, along with a review of the literature. Patients and Method: This retrospective study was conducted in the neurosurgery department of the Fann National University Hospital Center over six years, from 2016 to 2022, covering 18 cases of acromegaly related to a GH adenoma. Sociodemographic, clinical, paraclinical, therapeutic, and evolutionary parameters were studied. Results: The average age was 42.8 years, with a sex ratio of 2, and an average diagnosis time of 5.27 years. Clinical diagnosis was suggested by dysmorphic and tumoral syndromes, then confirmed by biological data and imaging. We found one microadenoma, 11 macroadenomas, and six giant pituitary adenomas. All patients underwent transsphenoidal surgery. Complications were mainly transient diabetes insipidus. Postoperative assessments showed 13 total excisions, three residuals, 10 visual improvements, seven stable visual statuses, and 10 cases of hormonal remission. Conclusion: Acromegaly is a clinical manifestation of GH adenomas, which remain rare. We collected 18 cases of somatotropic adenoma, all operated on with good clinical, radiological, and hormonal outcomes.