TITLE:
Association between History of Induced Abortion and Subsequent Risk of Gestational Diabetes Mellitus
AUTHORS:
Weiye Wang, Sisi Hu
KEYWORDS:
Gestational Diabetes, Diabetes, Induced Abortion, Abortion, Pregnancy
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.13 No.1,
January
27,
2025
ABSTRACT: Background: Some studies have indicated a potential link between a history of induced abortion (IA) and the subsequent risk of gestational diabetes mellitus (GDM), but the relationship is not fully understood, and the aim of this study was to further elucidate the association. Methods: The case-control study was conducted at 2 hospitals in central China from April 2018 to October 2020. GDM was diagnosed by an oral glucose tolerance test (OGTT). Information on history of IA was obtained through a face-to-face interview. Results: Among 396 GDM cases and 904 controls, the proportion of participants with history of IA in the case group was 30.6%, which was higher than that in the control group (23.1%), and the difference was statistically significant (p = 0.005). After adjusting for potential confounders, women with a history of IA had an increased subsequent risk of GDM compared with women without (OR, 1.24, 95% CI, 1.10 - 1.40, p = 0.002). The subsequent risk of GDM in pregnant women increased as the number of previous IAs increased (p for trend was equal to 0.004). Stratified analysis showed that women with a history of medical abortion (OR, 1.28, 95% CI, 1.01 - 1.62, p = 0.048) or surgical abortion (OR, 1.20, 95% CI, 1.04 - 1.38, p = 0.024) both had an increased subsequent risk of GDM compared with women without. Conclusion: History of IA, either medical or surgical, was related to an increased risk of GDM in subsequent pregnancy. The greater the number of previous IAs, the greater the subsequent risk of GDM.