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https://doi.org/10.1007/s00702-002-0797-1

has been cited by the following article:

• TITLE: Nucleotide Relative Molecular Similarity within Anti-Emetic/Pro-Kinetic Drug Structures

  AUTHORS: Wynford Robert Williams

  KEYWORDS: Gastroparesis, Adenine Nucleotides, Neurotransmitter Agents, Molecular Structure

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.13 No.1, January 21, 2025

  ABSTRACT: The physiology of the central and enteric nervous systems and gastric muscle contributes to the complexities encountered in the research and clinical management of gastroparesis. A wide range of prescription drugs target the underlying neurotransmitter imbalances and adjust nucleotide levels in appropriate tissues, but treatment is unsatisfactory, as our understanding of the condition is far from complete. In this study, computational software is used to focus on the adenine nucleotide, ATP, as a comparative template for the structures of drugs used in gastroparesis treatment. The results demonstrate that muscarinic, dopamine, serotonin (5-HT) and histamine receptor ligand classes relate structurally and differentially to the molecular structure of ATP. In these neurotransmitter classes, compounds do not target cell membrane receptor G-protein signal transduction in a manner that provides a single mechanism for improving gastroparesis symptoms. The exploration of alternative nucleotide-based deficiencies of KATP channels, Na+/K+ATPases and guanine nucleotide directed nitrergic mechanisms should enhance our experimental approach to understanding this condition.