Kimura, M., Oe, M., Okuyama, Y., Yoshioka, S. and Inagawa, H. (2019) TLR4 Reactivity of Gluconacetobacter (Gluconacetobacter hansenii GK-1）and Their Synergistic Action with Lactobacillus in Producing Antiallergic Effects. Japanese Pharmacology & Therapeutics, 47, 2001-2006. (In Japanese)

has been cited by the following article:

• TITLE: Effects of Acetic Acid Bacteria (Gluconacetobacter hansenii GK-1) on Fatigue Induced by Temporary Mental Stress: A Randomized, Double-Blind, Placebo-Controlled Study

  AUTHORS: Wei Wang, Mariko Oe, Mengwei Yuan, Keiko Kuriyama, Yumi Takeda, Mamoru Kimura, Ryosuke Matsuoka, Kiichi Sugiyama, Naoki Miura

  KEYWORDS: Acetic Acid Bacteria, Gluconacetobacter hansenii GK-1, Fatigue, Temporary Mental Stress, Double-Blind Study

  JOURNAL NAME: Food and Nutrition Sciences, Vol.16 No.1, January 13, 2025

  ABSTRACT: Objective: This study assessed the effects of consuming acetic acid bacteria (Gluconacetobacter hansenii GK-1) for 12 weeks on fatigue induced by temporary mental stress. Methods: This randomized, double-blind, placebo-controlled, parallel-group study included 100 healthy male and female adults aged 20 - 64 years. Participants consumed either the G. hansenii GK-1 supplement (9 × 10⁹ cells/day) or a placebo daily for 12 weeks. The impact of temporary mental stress on fatigue in G. hansenii GK-1 was assessed using a Visual Analog Scale (VAS) before the study began and after 12 weeks of supplementation. Results: Subjective fatigue measured by Visual Analog Scale (VAS) showed a significant decrease in fatigue induced by temporary mental stress after 12 weeks of consumption in the G. hansenii GK-1 group compared with the placebo group. No adverse events were attributed to G. hansenii GK-1. These findings confirm that continuous oral ingestion of G. hansenii GK-1 by healthy Japanese adults reduces feelings of fatigue caused by temporary mental stress.