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has been cited by the following article:

• TITLE: Chiral Method Development Using Polysaccharide-Based Chiral Stationary Phase (CSP) and Investigation of Chiral Column Degradation and Regeneration

  AUTHORS: Hua Zhao, Mary Ababat, Kyle Leeman, John Tucker

  KEYWORDS: Chiral Reversed-Phase HPLC Separation, Backflush, Chiral Column Regeneration, INGREZZA® (Valbenazine)

  JOURNAL NAME: American Journal of Analytical Chemistry, Vol.15 No.12, December 27, 2024

  ABSTRACT: Two polysaccharide-based chiral stationary phase columns were evaluated to improve the previous partial chiral peak separation to a baseline-resolved separation of the INGREZZA® drug substance and its diastereomers. Moreover, the tailing factor (Tf) variation was studied to investigate chiral column degradation and regeneration and to optimize chiral column performance and efficiency.