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https://doi.org/10.1021/cr00048a004

has been cited by the following article:

• TITLE: One-Pot Green Synthesis of 1, 4-Dihydropyridine Derivatives Using Polyindole TiO2 Nanocatalyst by Solvent Free Method

  AUTHORS: Deepak Babasaheb Phasage, Sanjay K. Sharma, Balram Tripathi, Sonia Chahar Srivastava

  KEYWORDS: TiO2, Nanocatalyst, Green Synthesis, Surface Morphology

  JOURNAL NAME: Open Journal of Composite Materials, Vol.14 No.3, June 14, 2024

  ABSTRACT: This study used a Polyindole in combination with TiO2 nanocatalyst as an efficient heterogeneous catalyst to carry out a multi-component Hantzsch reaction involving different aromatic aldehydes with methyl acetoacetate, and aqueous ammonium to create 1,4-dihydropyridine derivatives under solvent free condition at ambient temperature. A broad range of aldehydes and methyl acetoacetates, ranging from heteroaromatic to polyaromatic one, with high level of functional group tolerance can be used to provide the desired products possessing relevant medicinal moiety in high yields. This technology has prospective advantages over current protocols, including the utilization of a cheap, stable, recyclable, and safe catalyst, quicker reaction times with higher yields and simple product isolation.