Li, J.T., Song, S.F., Huang, W.W., Fan, H.Y. and Zhou, Z.Z. (2023) Novel Drug-Drug Salts of Enoxacin with Enhanced Antibacterial Activity: Insights from Solubility and Lipid-Water Partition Coefficient. Journal of Molecular Liquids, 385, Article ID: 122443. https://doi.org/10.1016/j.molliq.2023.122443

has been cited by the following article:

• TITLE: Cocrystals of Enoxacin with Heptanedioic Acid: Preparation and Characterization

  AUTHORS: Linbing Huang

  KEYWORDS: Enoxacin, Cocrystal, Heptanedioic Acid

  JOURNAL NAME: Open Access Library Journal, Vol.10 No.10, October 30, 2023

  ABSTRACT: Enoxacin (EX), a third-generation fluoroquinolone, demonstrates broadspectrum antibacterial activities and is widely applied for the treatment of various bacterial infections. However, it is challenging to improve its antibacterial activity and drug resistance effects based on solubility changes owing to EX being categorized as a class II drug in the Biopharmaceutics Classification System (BCS). Based on improving the solubility of enoxacin (EX) to enhance the antibacterial activity in vitro, pharmaceutical cocrystals of EX with heptanedioic acid have been designed, synthesized and characterized. Comprehensive analysis structure and Hirshfeld surface reveal that the hydrogen bonds formed by the N atom in the piperazine ring from EX molecule with the carboxylic acid group in the coformer could form a stable crystal structure. In summary, this study provides new insights to solid form of EX.