Casadei, V., Sarti, D., Milandri, C., Dentico, P., Guadagni, S. and Fiorentini, C. (2020) Comparing the Effectiveness of Pain Therapy (PT) and Modulated Electro-Hyperthermia (mEHT) versus Pain Therapy Alone in Treating Patients with Painful Bony Metastases: An Observational Trial. In: Szasz, A., Ed., Challenges and Solutions of Oncological Hyperthermia, Cambridge Scholars, Washington DC, Ch. 15, 337-345.

has been cited by the following article:

• TITLE: Stimulation and Control of Homeostasis

  AUTHORS: Andras Szasz

  KEYWORDS: Homeostasis, Vagus Stimulation, Heart-Rate Variability, Immune-Stimuli, Cancer, Time-Fractal Modulation, Bifurcations, 1/f Noise, mEHT, Personalized Therapy

  JOURNAL NAME: Open Journal of Biophysics, Vol.12 No.2, March 22, 2022

  ABSTRACT: Healthy homeostasis is a principal driving force of the dynamic equilibrium of living organisms. The dynamical basis of homeostasis is the complex and interconnected feedback mechanisms, which are fundamentally governed by the nervous system, mainly the balance of the sympathetic and parasympathetic controlling actions. The balancing regulation is well presented in the heart’s sinus node and can be measured by the time-domain heart-rate variation (HRV) of its frequency domain to analyze the constitutional frequencies of the variation. This last is a fluctuation that shows 1/f time fractal arrangement (f is the composing frequency). The time-fractal arrangement could depend on the structural fractal of the His-Purkinje system of the heart and personally modify the HRV. The cancers gradually destroy the homeostatic harmony, starting locally and finishing systemically. The controlling activity of vagus-nerve changes the HRV or the power density spectrum of the signal fluctuations in malignant development, presenting an appropriate control of the cancerous processes. The modified spectrum by a non-invasive radiofrequency treatment could arrest the tumor growth. An appropriate modulation could support the homeostatic control and force reconstructing of the broken complexity.