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https://doi.org/10.2174/1568010023344913

has been cited by the following article:

• TITLE: Design, Synthesis of Analgesics and Anticancer of Some New Derivatives of Benzimidazole

  AUTHORS: Helmy M. Sakr, Rezk R. Ayyad, Kazem Mahmoud, Ahmed M. Mansour, Ahmed. G Ahmed

  KEYWORDS: Benzimidazole, Analgesics and Anticancer

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.11 No.3, September 30, 2021

  ABSTRACT: This work, contains some new compounds from benzimidazole derivatives, which are synthesized by condensation of Orthophenylene diamine and Carbon disulfide resulting in 2-Mercapto-benzimidazole which is treated by alcoholic potassium hydroxide forming potassium salt of 2-mercaptobenzimidazole which reacts with different substances (alkyl chloroacetates, chloroacetic chloride, alkyl halides) also the ethoxy carbonyl methyl thiobenzimidazole reacts with different amines. In addition to chloromethyl benzimidazole which resulted from the reaction between orthophenylene diamine and chloroacetic acid, which reacted with different amines. The synthesized compound tested as analgesics and anticancer activity the new derivatives revealed moderate, strong and very strong analgesics and moderate and strong anticancer activity.