TITLE:
Clinical Study of Changmaile II Combined with Estrogen and Progesterone in Preventing and Treating Intrauterine Adhesion
AUTHORS:
Qian Liu, Xueli Chen
KEYWORDS:
Intrauterine Adhesion, Changmaile II, Estrogen/Progesterone
JOURNAL NAME:
Chinese Medicine,
Vol.12 No.2,
June
11,
2021
ABSTRACT: Purpose: To explore the clinical efficacy of Changmaile II
combined with cyclic estrogen/progesterone therapy in treating
hypomenorrhea caused by intrauterine adhesion
(IUA) and its effect on the endometrium after the separation procedure
for intrauterine adhesion. Methods: Sixty
patients with IUA confirmed by hysteroscopy in the Second People’s Hospital of
Fujian University of Traditional Chinese Medicine from March 2020 to December
2020 were selected and randomly divided into the control group and the
observation group, with 30 cases in each group. After the separation procedure
for intrauterine adhesion, the observation group underwent the cyclic
estrogen/progesterone therapy alone, while the observation group was
administered the in-hospital preparation of Changmaile II in addition to the
therapy of the observation group. Menstrual recovery, endometrial thickness,
and the diagnostic grading scores of IUA after 3 menstrual cycles were measured
in both groups. Results: After
the treatment for 3 menstrual cycles, the total effective rate was higher in
the observation group (73.33%) than in the control group (53.33%) (P 0.05). After treatment, the
diagnostic grading scores of IUA were higher in the observation group than in
the control group (P Conclusions: Changmaile II combined with estrogen and progesterone artificial cycle
therapy could increase the menstrual volume and endometrial thickness of
patients with intrauterine adhesion, while promoting the endometrial repair,
with better
efficacy than artificial cycle therapy alone.