TITLE:
Post-Acute Sequelae of SARS-Cov-2 Infection Associating Peripheral, Autonomic and Central Nervous System Disturbances: Case Report and Review of the Literature
AUTHORS:
David S. Younger
KEYWORDS:
COVID-19, SARS-CoV-2, Long Hauler, Long Covid, Peripheral Neuropathy, Dysautonomia, Encephalopathy, Encephalitis, EMG NCS, Tilt Table Test, Epidermal Nerve Fibers, PET/MRI
JOURNAL NAME:
World Journal of Neuroscience,
Vol.11 No.1,
February
2,
2021
ABSTRACT: Aim: To describe post-infectious neurological aspects of COVID-19 in a
patient with progressive post-infectious peripheral (PNS), autonomic (ANS) and
central nervous system (CNS) involvement due to SARS-CoV-2 infection. Background and Purpose: A variety of neurological manifestations have been
described in association with Covid-19, however, progressive multisystem neurological aspects have not been described. Methods: A case report detailing the history, examination, and infectious serology
associated with SARS-CoV-2, and subsequent neurodiagnostic laboratory testing
and treatment. Results: Neurodiagnostic laboratory studies showed large-fiber
demyelinating sensorimotor and painful small fiber sensory polyneuropathy,
orthostatic hypotension, and hypometabolism of bilateral anterior and mesial
temporal lobes with a possible frontal seizure focus. Treatment was initiated
with high-dose immune globulin therapy. Conclusions: The combination of
PNS, ANS and CNS involvement in this
patient was associated with post-infectious acquired immunity to SARS-CoV-2.