TITLE:
Prenatal Diagnosis and Management of Fetal Goiter Treated Successfully with Intra-Amniotic Levothyroxine
AUTHORS:
Valentina Corda, Cristina Peddes, Ambra Iuculano, Giovanni Monni
KEYWORDS:
Fetal Goiter, Prenatal Diagnosis, Prenatal Therapy, Amniocentesis, Fetal Thyroid, Fetal Ultrasound, Levothyroxine (L-T4)
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.11 No.1,
January
26,
2021
ABSTRACT: Goiter
is an enlargement of the thyroid gland which can be associated with a number of
complications both for the mother and the fetus. A 34-year-old pregnant woman
with normal thyroid function was referred to our Department of Obstetrics and
Gynecology at Microcitemico Pediatric Hospital, Cagliari, for suspected fetal
goiter at 32 gestational weeks. The case was monitored regularly by ultrasound
and treated successfully with intra-amniotic levothyroxine (L-T4)
administration. Fetal goiter was observed to decrease after this treatment and
the thyroid ultrasound findings were also normal both at birth and in
subsequent follow-ups. Our case report confirms the feasibility of conservative
treatment with L-T4, which can effectively prevent complications related to
fetal goiter.