TITLE:
Analysis of Clinical Characteristics and Diagnostic Value of Fungal Serology in Patients with Invasive Candidiasis
AUTHORS:
Heqiu Ruan, Weihua Xu, Mengjuan Xia, Zhichao Ma, Shengmiao Fu, Xinping Chen
KEYWORDS:
Invasive Candidiasis, Mannan, (1 - 3)-β-D Glucan, Combination of Serological Tests
JOURNAL NAME:
Open Journal of Medical Microbiology,
Vol.10 No.4,
December
29,
2020
ABSTRACT: Objective: To
evaluate the diagnostic value of (1 - 3)-β-D
glucan and mannan assay for invasive candidiasis. Methods: A
retrospective study was conducted on 32 cases in the disease group (18 proven
invasive candidiasis and 14 probable invasive candidiasis) and 48 cases in the
control group. The subjects were recruited from January 2018 to March 2019 in
Clinical Laboratory of Hainan General Hospital. All subjects were detected by (1
- 3)-β-D glucan and mannan assay. Results: The
mean concentration of (1 - 3)-β-D
glucan in the disease group was 97.45 (43.23, 224.35) pg/ml and it was
significantly higher than the mean concentration of the control group which was
49.85(41.91, 56.07) pg/ml (P =
0.005). The mean concentration of mannan in the disease group and the control
group were 161.36 (34.96, 224.49) pg/ml and 25.80 (25.00, 29.31) pg/ml,
respectively, which were significantly different (P β-D glucan assay were 59.38%, 89.58%, 79.17%, 76.79%, respectively.
The sensitivity, specificity, positive predictive value and negative predictive
value of mannan assay were 65.63%, 95.83%, 91.30%, 80.70%, respectively. The
sensitivity, specificity, positive predictive value and negative predictive
value of combination of two types of assays were 81.25%, 85.42%, 78.79% and 87.23%,
respectively. Conclusions: Combination
of (1 - 3)-β-D glucan and mannan
assay can improve diagnostic specificity and it has essential clinical
diagnostic value for invasive candidiasis.