Ohuma, E.O., Okiro, E.A., Ochola, R., Sande, C.J., Cane, P.A., Medley, G.F., Bottomley, C. and Nokes, D.J. (2012) The Natural History of Respiratory Syncytial Virus in a Birth Cohort: The Influence of Age and Previous Infection on Reinfection and Disease. American Journal of Epidemiology, 176, 794-802.
https://doi.org/10.1093/aje/kws257

has been cited by the following article:

• TITLE: Sero-Epidemiological Study of Respiratory Syncytial Virus

  AUTHORS: Mami Niida, Tetsuo Nakayama, Eitaro Suzuki

  KEYWORDS: RSV, Sero-Epidemiology, Neutralizing Antibody, IgG Enzyme Immunoassay

  JOURNAL NAME: Open Journal of Pediatrics, Vol.10 No.3, September 25, 2020

  ABSTRACT: Background: Respiratory syncytial virus (RSV) is one of the major viruses that cause respiratory infections in all generations, not only in neonates and infants. There is a limited number of reports on serological epidemiology of RSV subgroups A and B. Neutralizing test (NT) antibody reflects protective immunity but bothersome. Sero-epidemiological study should be performed using practical NT method. Methods: Two wild-type viruses subgroups A and B, isolated in 2013, and the Long strain was used as the challenge viruses. NT antibody with 100% inhibition of cytopathic effect (CPE) was examined. A total of 91 serum samples obtained from 0 to 12 years subjects without RSV infection who visited our hospital with some health problems and 121 sera obtained from healthy subjects in different age groups were used. Serological epidemiology of subgroups A and B was investigated in this study using new NT methods. Results: 1) A simple and practical NT method was developed. 2) The NT antibody titer was lowest in × 21.70 ± 2.03 against subgroup A and 5 × 20.85 ± 1.31 against subgroup B) and increased in 3 years of age or older, and high antibody titers were maintained during school age. 3) A slight difference was observed in the NT antibody titers against subgroups A and Bin young children Conclusions: A simple NT assay method was developed in the present study. By the age of 3 years, high NT antibody titers were observed and maintained until 12 years. The IgG (EIA) values decreased with age. No association was observed between IgG (EIA) and NT titers.