TITLE:
Progress in Research on 5-HTTLPR under Stress and Thyroid Papillary Carcinoma
AUTHORS:
Liumei Luo, Juncheng Guo, Fengxia Chen, Min Guo, Ping Huang
KEYWORDS:
5-HTTLPR, Hyroid Papillary Carcinoma, Central Nervous System, Clinical Diagnosis, Treatment
JOURNAL NAME:
Journal of Behavioral and Brain Science,
Vol.9 No.9,
September
11,
2019
ABSTRACT: The central nervous system plays an important role in regulating thyroid hormone homeostasis. 5-HT is one of the important neurotransmitters involved in energy balance regulation. 5-HT transporters affect 5-HT function by regulating SERT protein expression and transcriptional activity. Based on the biological correlation between thyroid hormone and thyroid tumors, 5-HTTLPR is associated with thyroid tumors under stress. Animal models of thyroid disease have shown that some of the transmitters in the brain’s monoaminergic nervous system have changed, and when the monoamine transporter gene expression is altered, it is found that this disorder is more pronounced. This article discusses whether thyroid papillary carcinoma patients are associated with 5-HTTLPR and whether the mechanism of thyroid papillary carcinoma “gene x environment” has an effect. Briefly describe the role of 5-HTTLPR in the development of patients with papillary thyroid carcinoma, and provide a basis for clinical diagnosis and treatment of papillary thyroid cancer.