TITLE:
The Keys to Optimising Breast Wounds: A Meta-Analysis
AUTHORS:
Stephanie Mary Anne Vincent, Mary Gallagher, Alison Johnston, Risal Djohan, Manvydas Varzgalis, Michael Sugrue
KEYWORDS:
Breast Wound Care, Breast Wound Infection, Breast Surgical Site, Adverse Outcomes, Breast Implant Loss, Return to the Operating Theatre
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.8 No.3,
June
28,
2019
ABSTRACT: Background: Breast disease and breast
cancer management form a major part of healthcare delivery. Surgical site
occurrence (SSO) poses septic and oncological risks to patients. This
study undertook a meta-analysis to identify key risk factors and interventions
that may alter the incidence of SSO in patients undergoing breast surgery. Methods: An ethically approved, PROSPERO-registered meta-analysis following PRISMA guidelines and
Cochrane Handbook for Systematic Reviews was undertaken of all published
English articles using electronic databases from 2010 to 2017 incorporating
MeSH terms “risk factors”, “surgical site infections”, “breast surgery”, and
“interventions”. Articles scoring > 10 for non-comparative studies and
>15 for comparative studies, using MINORS criteria were included. The OR or
RR using random-effects, Mantel-Haenszel method were computed for each risk
factor and intervention respectively with RevMan 5. Results: The pre-operative factors
affecting breast surgery SSO were diabetes mellitus (OR = 2.52, CI = 1.78 -
3.59, p Conclusions: This study identified key factors associated with increased risk of breast surgery
wound occurrence. It will facilitate the development of a peri-operative breast
wound bundle to optimize outcomes.