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has been cited by the following article:

• TITLE: Synthesis of Novel 4-Thiazolidinone and Bis-Thiazalidin-4-One Derivatives Derived from 4-Amino-Antipyrine and Evaluated as Inhibition of Purine Metabolism Enzymes by Bacteria

  AUTHORS: Reda M. Abdel Rahman, Abdulrahman S. Alharbi, Nawaa A. Alshammari

  KEYWORDS: Synthesis, 4-Thiazolidinones, Antipyrine, Inhibition of Purine Metabolism Enzymes, Bacteria

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.9 No.2, June 12, 2019

  ABSTRACT: Novel 4-thiazolidione and 1,4-bis-thiazolidinone derivatives bearing antipyrine moiety have been obtained from condensation of 4-aminoantipyrine 1 with aromatic/heteroaldehydes followed by cycloaddition with mercaptoacetic acid in nonpolar solvents. Structure of the products has been deduced upon their elemental analysis and spectral measurements. Most of the targets evaluated as enzymatic effect towards some bacteria (E. coli) in compare with Xanthine oxidase (from buttermilk) where the role of compounds is an inhibition of purine metabolism enzymes caused by E. coli.