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has been cited by the following article:

• TITLE: Anti-Aging Effect of Cynara cardunculus L. var. Cynara scolymus L. Extract in D-Galactose-Induced Skin Aging Model in Rats

  AUTHORS: Galina Sukoyan, Edisher Tsivtsivadze, Veronika Golovach, Tamara Kezeli, Natalya Demina

  KEYWORDS: Skin, Aging, Collagen, Pure Water Cynara cardunculus L. var. Cynara scolymus L. Extract, Nuclear Transcription Factor Kappa B

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.9 No.10, October 26, 2018

  ABSTRACT: The aim of the study was to evaluate the efficacy of 2% Cynara scolymus L. extracts in reverse disturbances of collagen metabolism and inflammation in D-galactose induced skin aging model in rats. D-galactose induced aging reproduced in 48 animals of main group, and 12 rats in control group. All animals in main group were randomized for 4 groups: I. aging + saline, II - IV. different manufacturers 2% artichoke extracts (with content of chlorogenic acid 2.5%) in a dose of intradermal injection 0.13 mg twice at weeks during 4 weeks. Influence of artichoke extracts restored skin relative weight and led to an increase of solubility in neutral salt and acid, and decreased pepsin solubility collagen fraction, restored the hexosamine/collagen (hydroxyproline) ratio and decreased the activity of nuclear transcription factor (NF-kB). Local prolonged treatment with artichoke extracts improved collagen metabolism and attenuated the progression of inflammation in D-galactose induced skin aging model.