Fitzpatrick, A.M., Teague, W.G., Holguin, F., Yeh, M., Brown, L.A. and Severe Asthma Research Program (2009) Airway Glutathione Homeostasis Is Altered in Children with Severe Asthma: Evidence for Oxidant Stress. Journal of Allergy and Clinical Immunology, 123, 146-152.e8.
https://doi.org/10.1016/j.jaci.2008.10.047

has been cited by the following article:

• TITLE: Environmental Exposure Associated with Oxidative Stress Biomarkers in Children and Adolescents Residents in Brazilian Western Amazon

  AUTHORS: Beatriz Fátima Alves de Oliveira, Leandro Vargas Barreto de Carvalho, Dennys de Souza Mourão, Rita de Cássia Oliveira da Costa Mattos, Hermano Albuquerque de Castro, Paulo Artaxo, Washington Leite Junger, Sandra Hacon

  KEYWORDS: Redox Imbalance, Glutathione S-Transferase, Thiol Groups, Malondialdehyde, Brazilian Amazon

  JOURNAL NAME: Journal of Environmental Protection, Vol.9 No.4, April 30, 2018

  ABSTRACT: Oxidative stress is a biological process that occurs in response to an imbalance between prooxidant and antioxidant substances and has been described in the pathophysiology of more than 200 clinical disorders. In this study, we evaluate the relationship between genetic, demographic, social, environmental, and health factors and redox imbalance biomarkers in a group of children and adolescents environmentally exposed to atmospheric pollutants and mercury in the Brazilian Western Amazon. This is a cross-sectional study of the relationship between demographic, genetic, and socioenvironmental factors and serum concentrations of redox imbalance biomarkers (thiol groups, malondialdehyde, and glutathione S-transferase [GST]) in children and adolescents living in the municipality of Porto Velho, Rondônia. The investigated factors were hierarchically organized into groups of variables and their relationship with redox imbalance biomarkers was estimated by a multiple linear regression model. Children and adolescents with asthma, with C-reactive protein values, with the polymorphic variant GSTP1, and exposed to indoor air pollution presented lower thiol serum concentrations when compared to those categorized in their respective reference groups. GST activity and malondialdehyde serum concentrations were positively related to weekly fish consumption and exposure to PM2.5. This study showed that enzymatic GST activity and malondialdehyde serum concentrations are positively associated with environmental factors, especially air pollution (β = 8.64 U/L for GST and β = 0.244 µmol/L for MDA in high exposure group; p-value