TITLE:
Association of Serum Soluble Receptor for Advanced Glycation End Products (sRAGE), S100A12, and VCAM-1 Levels with Further Post-Coronary Angiogram Endothelial Injury in Elderly and Younger Patients
AUTHORS:
Deeraj Mungun, Iyan Zakaria, Xiangming Wang, Tiantian Tu, Chuyan Feng, Yan Guo
KEYWORDS:
Coronary Angiography, Typical sRAGE, VCAM-1, S100A12
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.8 No.1,
January
24,
2018
ABSTRACT: Objective: Coronary Angiography (CAG) refers to an aggressive process that is likely to lead to endothelial injury and possibly drive further interpretation of the cause for patients within current atherosclerotic illnesses. Therefore, this study aims to test certain correlations among concentration of sRAGE, VCAM-1, as well as S100A12 pre- and post-coronary angiography alongside likelihood of endothelial injury among various patients in different ages including the younger and the geriatric groups, thereby offering a full connection upon CAG impacts of patients having atherosclerosis. Method: In this study, the whole patients chosen had been grouped into two major groups on the basis of ages: the younger patient aged less than 65 years old (Group 1), and the elderly patient aged over 65 years old (Group 2). Soluble RAGE (sRAGE), VCAM-1 and S100A12 degrees in blood sampling gathered followed by measurements of CAG session for evaluating the inflammatory responses and likelihood of endothelial injury caused via CAG. All data was analyzed using SPSS version 21.0. Findings: Significant enhancement among concentration of serum VCAM-1 (P = 0.007) in younger patients and sRAGE (P = 0.019) in elderly patients had been observed, but that of serum S100A12 was still unaltered. Conclusions: Enhanced concentration of sRAGE and VCAM-1 post-CAG of patients having CAD are able to be related to follow-up endothelial injury, thus contributing to different pathway in exacerbating endothelial injury among younger and elderly patients.