M. J. Balunas and A. D. Kinghorn, “Drug Discovery from Medicinal Plants,” Life Sciences, Vol. 78, No. 5, 2005, pp. 431-441. doi:10.1016/j.lfs.2005.09.012

has been cited by the following article:

• TITLE: Isolation, Identification and Tyrosinase Inhibitory Activities of the Extractives from Allamanda cathartica

  AUTHORS: Kosei Yamauchi, Tohru Mitsunaga, Irmanida Batubara

  KEYWORDS: Allamanda c athartica, Tyrosinase, Glabridin, Kaempferol, Naringenin, Allamandicin

  JOURNAL NAME: Natural Resources, Vol.2 No.3, September 29, 2011

  ABSTRACT: Tyrosinase inhibitory activity of the extractives from A. cathartica was examined and their new bioactivity and potent active compounds were identified. Five compounds, glabridin, new lignan, kaempferol, naringenin, and allamandicin, were isolated by a series of chromatography, and identified by NMR and LC-MS. Among them, glabridin had the high-est tyrosinase inhibitory activity (IC50:2.93 μM) which is 15 times stronger than that of kojic acid used as positive con-trol (IC50:43.7 μM). Moreover the lignan was indentified as 1-[3-(4-allyl-2,6-dimethoxyphenoxy)-4-methoxyphenyl] propane-1,2,diol which was a novel lignan.