Article citationsMore>>
Faesen, A.C., Dirac, A.M., Shanmugham, A., Ovaa, H., Perrakis, A. and Sixma, T.K. (2011) Mechanism of USP7/HAUSP Activation by Its C-Terminal Ubiquitin-Like Domain and Allosteric Regulation by GMP-Synthetase. Molecular Cell, 44, 147-159.
https://doi.org/10.1016/j.molcel.2011.06.034
has been cited by the following article:
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TITLE:
N-Myc Inhibition: Advances in Neuroblastoma Treatment
AUTHORS:
Md Kamrul Hasan
KEYWORDS:
Neuroblastoma, N-Myc, PI3K/mTOR, PARP1, PD-L1, HAUSP
JOURNAL NAME:
CellBio,
Vol.6 No.3,
September
30,
2017
ABSTRACT: Neuroblastoma (NBL) is one
of the most common solid tumors and around 15% of cancer mortality in children.
Amplification of the N-Myc proto-oncogene is strongly correlated with
advanced disease and poor clinical outcome in NBL. Recent studies described
that ubiquitin-specific protease 7 (USP7; also known as HAUSP) interacts with
N-Myc, induces deubiquitination and subsequent stabilization of N-Myc that
in-turn potentiates N-Myc
function, and treatment with the HAUSP inhibitor (P22077) blocked such effects.