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Chesler, L., Schlieve, C., Goldenberg, D.D., Kenney, A., Kim, G., McMillan, A., et al. (2006) Inhibition of Phosphatidylinositol 3-Kinase Destabilizes Mycn Protein and Blocks Malignant Progression in Neuroblastoma. Cancer Research, 66, 8139-8146.
https://doi.org/10.1158/0008-5472.CAN-05-2769
has been cited by the following article:
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TITLE:
N-Myc Inhibition: Advances in Neuroblastoma Treatment
AUTHORS:
Md Kamrul Hasan
KEYWORDS:
Neuroblastoma, N-Myc, PI3K/mTOR, PARP1, PD-L1, HAUSP
JOURNAL NAME:
CellBio,
Vol.6 No.3,
September
30,
2017
ABSTRACT: Neuroblastoma (NBL) is one
of the most common solid tumors and around 15% of cancer mortality in children.
Amplification of the N-Myc proto-oncogene is strongly correlated with
advanced disease and poor clinical outcome in NBL. Recent studies described
that ubiquitin-specific protease 7 (USP7; also known as HAUSP) interacts with
N-Myc, induces deubiquitination and subsequent stabilization of N-Myc that
in-turn potentiates N-Myc
function, and treatment with the HAUSP inhibitor (P22077) blocked such effects.