TITLE:
Clinical Assessment of a Mesotherapy Formulation for Skin Rejuvenation in Healthy Volunteers
AUTHORS:
Anne Grand-Vincent, Sylvie Boisnic, Catherine Salomon, Pascal Prinderre, Philippe Piccerelle
KEYWORDS:
Mesotherapy, Skin Rejuvenation, Multi-Component Solution Crow’s-Feet Wrinkles, Pore Size, Dermis Density, Dermis Thickness
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.7 No.4,
November
10,
2017
ABSTRACT: Mesotherapy is a mildly invasive procedure involving
several subcutaneous drug injections, which are performed simultaneously. The
concept is to inject a very small amount of active compounds (hyaluronic acid,
vitamins, antioxidants, enzymes, humectants, …) and the aim is to stimulate the
biosynthetic capacity of fibroblasts, increase collagen and elastin production
and to give active essential molecules for a fibroblasts environment. Numerous
studies suggest that the mesotherapy procedure improves skin hydration and mechanical
properties; however, some results have not been statistically significant. In
this study, we investigated an antiaging treatment as a complementary approach
to a non-surgical rejuvenating procedure after 5 sessions of mesotherapy. Our
main objective was to assess the improvement of face, neck and neckline skin
quality, after intradermal microinjections of NCTF 135HA®. This mixture, manufactured by FILORGA Laboratories,
includes a non-cross-linked hyaluronic acid, vitamins, antioxidants,
mineral salts and enzymes. A statistically significant decrease in the depth of
crow’s-feet wrinkles (43.3%) and in pore size (58.5%) was observed. Also,
dermatological scores showed a significant decrease, and data suggest that skin
tone was improved with a brighter tone. The injected mixture could then have an
action on the skin pigmentation process with a photoprotective effect. Evolution
of Dermis density was also investigated and an increase of dermal density and
thickness were highlighted, showing an improvement of skin firmness with
significant increases of dermis thickness (20%) and dermis density (24%), indicating
a neocollagen activity.