TITLE:
Reactivity of 1-methylisoquinoline synthesis of pyrazolyl triazoloisoquinoline and thia-diazolyl isoquinoline derivatives
AUTHORS:
Hamdi M Hassaneen, Huwaida M. E Hassaneen, Yasmin Sh Mohammed
KEYWORDS:
[1, 2, 4]Triazolo[3, 4-a]isoquinolines; Enaminones; Hydrazonoyl Halides; Cycloaddition Reactions; Chitosan; Thioanilides; [1, 3, 4]Thiadiazolylisoquinoline Derivatives
JOURNAL NAME:
Natural Science,
Vol.3 No.8,
August
3,
2011
ABSTRACT: The reaction of 1-methylisoquinoline 1 with hy-drazonoyl halides 2 in ethanol in the presence of chitosan under microwave irradiation affords triazoloisoquinoline 4. Product 4 reacts with dimethylformamide-dimethylacetal to give ena- minones 7 which react with hydrazonoyl halides to give pyrazolyl triazoloisoquinoline 13. Also, 1-methylisoquinoline 1 reacts with arylisothio-cyanate to give thioanilide 15 which reacts with hydrazonoyl halides to give the corresponding thiadiazolyl isoquinoline derivatives 20, 24.