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https://doi.org/10.1111/jog.13081

has been cited by the following article:

• TITLE: Efficacy of Intra-Cystic Methotrexate Injection in Management of Benign Persistent Ovarian Cysts

  AUTHORS: Adel El Gergawy, Ahmed El Halwagy, Ayman S. Dawood, Mohamed E. Kabeil

  KEYWORDS: Simple Cyst, Methotrexate, Ultrasound Guided, Aspiration, Recurrence

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.7 No.1, December 30, 2016

  ABSTRACT: Aim: To evaluate and compare the efficacy of methotrexate injection in management of persistent simple ovarian cyst versus the use of transvaginal ultrasound aspiration alone. Patients and Methods: This randomized controlled study was conducted at Tanta University Hospitals in the period from April 1, 2016 to October 31, 2016. Patients were randomly allocated into two groups; each group has 25 patients with benign persistent simple ovarian cyst. Group I: Patients were subjected to transvaginal aspiration of the cyst. Group II: patients were subjected to methotrexate injection inside the cyst. Patients in both group were followed up at 1, 3, 6 months after procedure for the recurrence and occurrence spontaneous pregnancy. Results: The mean age in group I was 28.8 years, and the mean age in group II was 26.52 years with non-significant difference. Also there was non-significant difference between both groups regarding size of the cyst. No case recorded to have a cyst recurrence in group II and four cases in group I within six months with significant difference (P value 0.037), and there was non-significant differences as regard the pregnancy rate and complications. Conclusion: Transvaginal intra-cystic methotrexate injection is a safe and effective choice for management of persistent simple benign ovarian cyst.