Dupont, H., Gaillot, O., Goetgheluck, A.S., Plassart, C., Emond, J.P., Lecuru, M., Gaillard, N., Derdouri, S., Lemaire, B., Girard de Courtilles, M., Cattoir, V. and Mammeri, H. Molecular Characterization of Carbapenem-Nonsusceptible Enterobacterial Isolates Collected during a Prospective Interregional Survey in France and Susceptibility to the Novel Ceftazidime-Avibactam and Aztreonam-Avibactam Combinations. Antimicrobial Agents and Chemotherapy, 60, 215-221.
https://doi.org/10.1128/AAC.01559-15

has been cited by the following article:

• TITLE: Detection and Characterization of β-Lactamase Encoding Genes in Carbapenem Non-Susceptible Gram-Negative Bacteria and Susceptibility of Isolates to Ceftazidime-Avibactam at a New York City Community Hospital

  AUTHORS: Carl Urban, Rita Colon-Urban, Vincent J. LaBombardi, Noriel Mariano, Nishant Prasad, Geeti Dhillon, Marina Guralnik, Sorana Segal-Maurer

  KEYWORDS: Carbapenem Non-Susceptible, Check-MDR CT103 XL Microarray, β-Lactamase Detection, Resistance Mechanisms, Ceftazidime-Avibactam

  JOURNAL NAME: Open Journal of Medical Microbiology, Vol.6 No.4, December 19, 2016

  ABSTRACT: A surveillance study was undertaken to identify prominent β-lactamase encoding genes in 131 carbapenem non-susceptible gram-negative clinical isolates at a New York City community hospital. KPC carbapenemases were detected in 89% of Enterobacteriaceae as well as additional TEM, SHV, and CTX-M class A enzymes. OXA-23 and OXA-24 were the prevalent class D carbapenemases identified in Acinetobacter species. One OXA-23 in M. morganii and one OXA-48 in K. pneumoniae were also identified. Among class C β-lactamases CMY, ACT/MIR, DHA, and FOX were detected. The in vitro activity of ceftazidime-avibactam by E-test methodology was tested with minimal inhibitory concentrations (MIC) of ≤3 μg/ml for 97.8% of all Enterobacteriaceae, MIC50/90 of 16/>256 μg/ml for carbapenem non-susceptible Acinetobacter, and 3/6 μg/ml for carbapenem non-susceptible Pseudomonas aeruginosa. Periodic surveillance of isolates to characterize current and emerging β-lactamase genotypes present in local isolates may help identify outbreak situations, provide assistance to infection control and antibiotic stewardship programs, and potentially improve patient outcomes.