TITLE:
A Study of HELLP Syndrome among Cases of Pre-Eclampsia and Eclampsia: Incidence and Correlation of Laboratory Parameters
AUTHORS:
Priyadarshini Tiwari, Sona Bhalavi, Shubhangi Nayak, Rajesh Tiwari
KEYWORDS:
HELLP, Pre Eclampsia, Eclampsia, Microangiopathy, Hemolysis, Genetic
JOURNAL NAME:
Open Access Library Journal,
Vol.2 No.9,
September
8,
2015
ABSTRACT:
Objective: To determine the incidence of HELLP syndrome amongst cases of Eclampsia
and severe pre eclampsia admitted to our hospital and to study the correlation of
laboratory parameters with the mean arterial pressure (MAP) and with each other.
Method: 238 cases of severe pre eclampsia and eclampsia were studied for their clinical
features, laboratory parameters and outcome. Cases were divided into two groups: non HELLP and complete HELLP for comparison
of the maternal and perinatal outcome. The levels of Alanine Transaminase
(ALT) were compared against other laboratory parameters for correlation. The mean
arterial pressures (MAP) of the patients were computed to investigate whether its
levels had any correlation with the derangement of ALT. Statistical analysis was
done in SPSS software and spearman’s correlation was run for the laboratory parameters.
Results: No significant difference was seen in the maternal and perinatal mortality
in the two groups. ALT showed no correlation with MAP as with LDH, platelets and
hemoglobin and a weak but significant correlation with the parameters of renal function.
Conclusion: Our population shows a low incidence of HELLP syndrome; the hepatic
dysfunction correlates with the renal dysfunction without any correlation with the
MAP.