TITLE:
Beneficial Effects of Tibolone on Sexual Dys-function in Women with Premature Ovarian Failure (POF)
AUTHORS:
Florence E. Omu, Assem Elbiaa, Amal Ghafour, Ibrahim Gadalla, Alexander E. Omu
KEYWORDS:
Premature Ovarian Failure, Sexual Dysfunction, Tibolone, Replacement Therapy
JOURNAL NAME:
Health,
Vol.8 No.9,
June
21,
2016
ABSTRACT: Introduction: Premature Ovarian Failure (POF) is cessation of ovarian functions before the age of 40 years old with consequent cessation of menstruation. Objective of study: The aim of this study was to evaluate the association between Premature Ovarian Failure and sexual dysfunctions and outcome of management with tibolone. Patients and Methods: Thirty-one women with Premature Ovarian Failure seen at the outpatient clinic of Maternity Hospital were enrolled into the study with 31 healthy women as control group. The instrument of data collection included two types of questionnaires to assess the effect of Premature Ovarian Failure on sexuality. All the women with POF had oral tibolone 2.5 mg for at least one year and the second questionnaire and the profiles were repeated. Results: Of the 31 women with POF that presented with sexual dysfunction (SD), 27 (87.1%) complained of one or more SD domains such as reduced frequency of coitus, dyspareunia, vaginal dryness, reduced libido and general sexual satisfaction (P