TITLE:
The Relationship between Serum 25-Hydroxyvitamin D and Resistin Levels in Saudi Diabetic Patients
AUTHORS:
Ahmed El-Tahir, Abdulaziz F. AL-Kaabbab, Muaawia Ahmed Hamza, Abdullah A. Saeed, Abdulshakour Abdalla, May F. AlMohareb, Hana S. Alfaleh, Gwiria M. H. Satti
KEYWORDS:
25-Hydroxyvitamin D, Resistin, Diabetes Mellitus, Kingdom of Saudi Arabia
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.6 No.2,
February
29,
2016
ABSTRACT: Objectives: The aim of
this study was to investigate the relationship between the levels of 25-hydroxyvitamin
D and the adipokine resistin in Saudi diabetic patients and those at high risk
to develop atherosclerotic cardiovascular diseases. Methodology: One hundred
and sixty seven subjects were recruited for the cross-sectional study at King
Fahad Medical City, Saudi Arabia. Blood samples were analyzed for biochemical
parameters. Serum 25-hydroxyvitamin D and resistin levels were measured for all
the participants. Result: Fifty six type-1, 55 type-2 diabetic patients and 56
healthy controls were recruited. Serum 25-hydroxyvitamin D level in the control
group was 44.21 ± 41.80 μg/ml compared to 50.67 ± 35.60 μg/ml in the diabetic
group (P = 0.427) with no significant different between type-2 diabetes
mellitus and type-1 diabetes mellitus (P = 0.628). Resistin level in the
control group was 14.00 ± 7.39μg/ml compared to 20.21 ± 16.94 μg/ml in the
diabetic group (P ≤ 0.01), no significant difference between type-2 diabetes
mellitus and type-1 diabetes mellitus (P = 0.817). Resistin in those taking
vitamin D supplementation was 21.34 ± 18.27 μg/ml; and in those not taking
vitamin D supplementation, it was 17.4 ± 11.19 μg/ml; (P = 0.237). There was
significant negative correlation between 25-hydroxyvitamin D and resistin in
type-2 diabetes mellitus (P ≤ 0.043) and no significant correlation was found
between vitamin 25 (OH) D and resistin level in type-1 diabetes mellitus (P =
0.538). Blood urea and creatinine showed significant positive correlation with
vitamin 25 (OH) D in one hand and resistin level on the other hand. Discussion
and Conclusions: Severalin vitroandin
vivostudies have confirmed
that the vitamin 25 (OH) D have numerous important functions in the body. The
circulating vitamin 25 (OH) D and resistin levels were associated with general
inflammation in renal diseases. This study showed significant negative
correlation between resistin level and vitamin 25 (OH) D in type 2 diabetes
mellitus reflecting their roles in glucose homeostasis. The positive
correlation of resistin and vitamin D with urea may reflect their involvement
in kidney dysfunction. The level of serum resistin showed slight increase in
diabetic patients compared to control group and it was higher in type-2
diabetes mellitus. More efforts are needed to explore the physiological
mechanism of vitamin 25 (OH) D and resistin action in metabolic disorders.