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has been cited by the following article:

• TITLE: Extracellular Micro-RNAs in Health and Disease: Basic Science, Biogenesis and Release

  AUTHORS: Wael Nassar, Mervat El-Ansary, Tarek Fayyad, Mostafa Abdel Aziz

  KEYWORDS: Extracellular miRNAs, Extracellular Vesicles (EVs), Exosomes, Horizontal Gene Transfer (HGT), Microvesicles (MVs)

  JOURNAL NAME: American Journal of Molecular Biology, Vol.6 No.1, January 5, 2016

  ABSTRACT: Small non-protein coding micro-RNAs are regularly exported out of cells, both in health and disease. More than ninety percent of extracellular miRNAs are associated with lower-molecular-mass complexes bound to Argonaute 2 (Ago2), nucleophosmin-1 (NPM1) and high density lipoproteins (HDL), whereas the rest (~10%) are membrane-vesicle-encapsulated within exosomes, shedding microvesicles and apoptotic bodies. Regardless of the debate of the nature of circulating miRNA as byproducts of routine cell activities or mediators of cell-cell communication, proper understanding of the molecular behaviors of miRNA in health and disease, is expected to open a new gate for the discovery of new diagnostic tools and possibly therapeutic implementation in the near future.