TITLE:
Significance of Golgi Protein 73, Alpha-Fetoprotein and Vascular Endothelial Growth Factor Expression in Diagnosis of Primary Hepatic Cancer
AUTHORS:
Xinfeng Li, Xiaofu Li, Wenrui Zhou, Gaoxiong Wang, Wei Wang
KEYWORDS:
Golgi Protein 73, Alpha-Fetoprotein, Vascular Endothelial Growth Factor Expression
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.13,
December
3,
2015
ABSTRACT: Aim: We measured Golgi protein73 (GP73), alpha-fetoprotein (AFP), and
vascular endothelial growth factor (VEGF) expression in primary hepatic cancer
(PHC) and assessed their clinical significance. Methods: Forty-five PHC and
tumor-adjacent specimens and 14 normal liver specimens were examined. GP73, AFP,
and VEGF expression was measured via immunohistochemistry and a correlation of
protein expression with clinical pathology of PHC was suggested. Results: GP73,
AFP, and VEGF expression was significantly higher in PHC and tumor-adjacent tissue
compared to tumor-adjacent tissue (0.143 ± 0.018 vs. 0.124 ± 0.027, 0.116 ±
0.026 vs. 0.098 ± 0.014, and 0.126 ± 0.027 vs. 0.092 ± 0.016, respectively; all p 0.088 ± 0.029, 0.098 ± 0.014 vs. 0.073 ± 0.011, and 0.092 ± 0.016 vs. 0.076 ± 0.018, respectively; all p p