TITLE:
Toxicolological Test of Saponins from Sapindus mukorossi Gaerth
AUTHORS:
Menghao Du, Sumei Huang, Jinping Zhang, Jingwen Wang, Lisong Hu, Jingmin Jiang
KEYWORDS:
Saponins, Acute Oral Toxicity, Acute Dermal Toxicity, Dermal Irritation
JOURNAL NAME:
Open Journal of Forestry,
Vol.5 No.7,
October
21,
2015
ABSTRACT: The study
has been carried out to investigate acute oral toxicity, acute dermal toxicity
in SPF rats and dermal irritation in rabbits. The
result shows: 1) acute oral toxicity test shows that LD50 of saponins
from Sapindus mukorossi is 9260 mg/kg
(95% confidence interval is 6360 - 13,500 mg/kg) and 7940 mg/kg (95% confidence
interval is 4890 - 12,900 mg/kg); 2) acute dermal toxicity test shows that LD50 of saponins from Sapindus mukorossi is more than 5000 mg/kg in both female and male Wistar rats; 3) dermal irritation
test in rabbits shows that the average score of dermal irritation per day of
each rabbit is zero after 14 days of continuous dermal irritation. According to
the classification standard of toxicity in “Hygienic Standard for Cosmetics”
(2002 version), the sample is classified as “practical nontoxic” and “non dermal
irritation”. Thus, we can conclude that the saponin extraction from S. mukorossi Gaerth is safe for cosmetics.