TITLE:
Potential of Terpenoid Bioactive Compound Isolated from Papua Ant Nest as an Alternative Ovarian Cancer Treatment
AUTHORS:
Hasanuddin, K. Sofie Rifayani, G. Supriadi, Dikdik Kurnia, D. Adhita
KEYWORDS:
Terpenoid, Ovarian Cell Lines, Apoptotic Index
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.5 No.7,
July
21,
2015
ABSTRACT: Objectives: The purpose of
this study was to determine anticancer activity of terpenoid bioactive compound isolated from Papua ant
nest on ovarian cancer cells in vitro. Methods:
This was a laboratory experimental study which aims to determine the potential
of the terpenoid bioactive compound isolated from Papua
ant nest to inhibit the growth and induce apoptotic process on ovarian cancer
cells (SKO-3) in vitro. Result: Terpenoid had capability to
inhibit the growth of ovarian cancer cell line (SKO-3) in vitro, with IC50 of 481 ug/ml at 48 hours and 463
ug/ml at 48 hours, respectively. At a concentration of 600 ug/ml, terpenoid was
able to induce apoptotic process on ovarian cancer cell lines in vitro with the apoptotic index of 30%
at 24 hours, 35% at 48 hours and 37% at 72 hours, respectively. Conclusion: Terpenoid bioactive compound isolated from Papua ant
nest had the ability to inhibit the growth and was able to induce apoptotic
process on ovarian cancer cell lines (SKO-3) in vitro.